Activation of the renal GLP-1R leads to expression of Ren1 in the renal vascular tree
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- Activation of the renal GLP-1R leads to expression of Ren1 in the renal vascular tree
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The GLP-1 receptor (GLP-1R) in the kidney is expressed exclusively in vascular smooth muscle cells in arteries and arterioles. Downstream effects of the activation of the renal vascular GLP-1R are elusive but may involve regulation of the renin-angiotensin-aldosterone system (RAAS). The expression of Ren1 in the mouse renal vasculature was investigated by in situ hybridization after a single subcutaneous dose of liraglutide, semaglutide and after repeated injections of liraglutide. Single and repeated exposure to GLP-1R agonists induced expression of Ren1 in the renal vascular smooth muscle cell compartment compared with vehicle injected controls (p <.0001) for both semaglutide and liraglutide. The present data show a robust induction of Ren1 expression in the vascular smooth muscle cells of the kidney after single and repeated GLP-1R activation and this renin recruitment may be involved in the effects of GLP-1R agonist treatment on kidney disease.
Original language | English |
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Article number | e00234 |
Journal | Endocrinology, Diabetes and Metabolism |
Volume | 4 |
Issue number | 3 |
ISSN | 2398-9238 |
DOIs | |
Publication status | Published - 2021 |
- GLP-1, GLP-1 receptor, GLP-1R agonists, in situ hybridization, renal vasculature, renin recruitment
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