The Graduate Programme for In Vivo Pharmacology and Experimental Animals

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  1. 2021
  2. Published

    Insulin treatment improves liver histopathology and decreases expression of inflammatory and fibrogenic genes in a hyperglycemic, dyslipidemic hamster model of NAFLD

    Jensen, Victoria Svop, Fledelius, C., Zachodnik, C., Damgaard, J., Nygaard, H., Tornqvist, K. S., Kirk, R. K., Viuff, B. M., Wulff, E. M., Lykkesfeldt, Jens & Hvid, H., 2021, In: Journal of Translational Medicine. 19, 1, 80.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Temporal development of dyslipidemia and nonalcoholic fatty liver disease (Nafld) in syrian hamsters fed a high‐fat, high‐fructose, high‐cholesterol diet

    Jensen, Victoria Svop, Fledelius, C., Wulff, E. M., Lykkesfeldt, Jens & Hvid, H., 2021, In: Nutrients. 13, 2, p. 1-18 18 p., 604.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Development of an aerogenous Escherichia coli infection model in adult broiler breeders

    Kromann, Sofie, Olsen, Rikke Heidemann, Bojesen, Anders Miki, Jensen, Henrik Elvang & Thoefner, Ida , 2021, In: Scientific Reports. 11, 15 p., 19556.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Protective potential of an autogenous vaccine in an aerogenous model of escherichia coli infection in broiler breeders

    Kromann, Sofie, Olsen, Rikke Heidemann, Bojesen, Anders Miki, Jensen, Henrik Elvang & Thoefner, Ida , 2021, In: Vaccines. 9, 11, 1233.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    A reduced CP level without medicinal zinc oxide does not alter the intestinal morphology in weaned pigs 24 days post-weaning

    Larsen, Christina, Lynegaard, J. C., Pedersen, Anni Øyan, Kjeldsen, N. J., Hansen, C. F., Nielsen, Jens Peter & Williams, Charlotte Amdi, 2021, In: Animal. 15, 4, 100188.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    An Oligosaccharide Rich Diet Increases Akkermansia spp. Bacteria in the Equine Microbiota

    Lindenberg, F. C., Lützhøft, Ditte Olsen, Krych, Lukasz, Fielden, J., Kot, Witold, Frøkiær, Hanne, van Galen, G., Nielsen, Dennis Sandris & Hansen, Axel Kornerup, 2021, In: Frontiers in Microbiology. 12, 666039.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Hyperinsulinaemic hypoglycaemia in non-anaesthetized Göttingen minipigs induces a counter-regulatory endocrine response and electrocardiographic changes

    Lyhne, Mille Kronborg, Vegge, A., Povlsen, G. K., Slaaby, R., Kildegaard, J., Pedersen-Bjergaard, Ulrik & Olsen, Lisbeth Høier, 2021, In: Scientific Reports. 11, 11 p., 5983.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Modulation of nociception by amitriptyline hydrochloride in the Speke’s hinge-back tortoise (Kiniskys spekii)

    Musembi Makau, Christopher, Towett, P. K., Abelson, Klas & Kanui, T. I., 2021, In: Veterinary Medicine and Science. 7, 3, p. 1034-1041

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    High Parenteral Support Volume Is Associated With Reduced Quality of Life Determined by the Short‐Bowel Syndrome Quality of Life Scale in Nonmalignant Intestinal Failure Patients

    Nordsten, C. B., Mølsted, Stig, Bangsgaard, L., Fuglsang, K. A., Brandt, C. F., Niemann, Mads Jacob & Jeppesen, Palle Bekker, 1 Jul 2021, In: Journal of Parenteral and Enteral Nutrition. 45, 5, p. 926-932 7 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  11. Published

    The selective 5-HT2A receptor agonist 25CN-NBOH does not affect reversal learning in mice

    Odland, Anna Ulstein, Kristensen, Jesper Langgaard & Andreasen T., Jesper, 2021, In: Behavioural Pharmacology. 32, 5, p. 448-452

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Polymorphisms in the serotonin transporter gene and circulating concentrations of neurotransmitters in Cavalier King Charles Spaniels with myxomatous mitral valve disease

    Reimann, Maria Josefine, Fredholm, Merete, Cremer, Signe Emilie, Christiansen, L. B., Meurs, K. M., Møller, J. E., Häggström, J., Lykkesfeldt, Jens & Olsen, Lisbeth Høier, 2021, In: Journal of Veterinary Internal Medicine. 35, 6, p. 2596-2606

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Modelling Nonalcoholic Steatohepatitis In Vivo—A Close Transcriptomic Similarity Supports the Guinea Pig Disease Model

    Skat-Rørdam, Josephine, Ipsen, David Højland, Seemann, Ernst Stefan, Latta, M., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2021, In: Biomedicines. 9, 9, 18 p., 1198.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Differential effects of dietary components on glucose intolerance and non‐alcoholic steatohepatitis

    Skat-Rørdam, Josephine, Ipsen, David Højland, Hardam, P. D., Latta, M., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2021, In: Nutrients. 13, 8, 2523.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Modelling nonalcoholic steatohepatitis in vivo—a close transcriptomic similarity supports the guinea pig disease model

    Skat-Rørdam, Josephine, Ipsen, David Højland, Seemann, Ernst Stefan, Latta, M., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, Sep 2021, In: Biomedicines. 9, 9, 1198.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Identification of compounds responsible for the anthelmintic effects of chicory (Cichorium intybus) by molecular networking and bio-guided fractionation

    Valente, Angela Hørdum, de Roode, M., Ernst, M., Peña-Espinoza, M., Bornancin, L., Bonde, C. S., Martínez-Valladares, M., Ramünke, S., Krücken, J., Simonsen, H. T., Thamsborg, Stig Milan & Williams, Andrew Richard, 2021, In: International Journal for Parasitology: Drugs and Drug Resistance. 15, p. 105-114 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Hepatic Stellate Cell Activation and Inactivation in NASH-Fibrosis—Roles as Putative Treatment Targets?

    Zisser, Alexandra, Ipsen, David Højland & Tveden-Nyborg, Pernille, 2021, In: Biomedicines. 9, 4, 365.

    Research output: Contribution to journal › Review › Research › peer-review

  18. 2020
  19. Published

    Nutrient Restriction has Limited Short-Term Effects on Gut, Immunity, and Brain Development in Preterm Pigs

    Ahnfeldt, Agnethe May, Bæk, Ole, Hui, Y., Nielsen, Charlotte Holme, Obelitz-Ryom, K., Busk-Anderson, T., Ruge, A., Holst, Jens Juul, Rudloff, S., Burrin, D., Nguyen, Duc Ninh, Nielsen, Dennis Sandris, Zachariassen, G., Bering, S. B., Thymann, Thomas & Sangild, Per Torp, 2020, In: The Journal of Nutrition. 150, 5, p. 1196-1207

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Insulin Treatment Attenuates Small Nerve Fiber Damage in Rat Model of Type 2 Diabetes

    Andreasen, L. J., Kirk, R. K., Fledelius, C., Yorek, M. A., Lykkesfeldt, Jens & Akerstrom, T., 2020, In: Journal of Diabetes Research. 2020, 13 p., 9626398.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Optimising the sampling procedure for forensic investigation of bruises on pigs

    Barington, Kristiane, Skovgaard, K., Henriksen, Nicole Lind & Jensen, Henrik Elvang, 2020, In: Veterinary Record. 187, 4, 153.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    The adjuvant-induced rat model of monoarthritis: welfare implications and possible refinement strategies

    Berke, M. S. & Abelson, Klas, 2020, In: Scandinavian Journal of Laboratory Animal Science. 46, 5, p. 39-50 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Return of the lysergamides. Part VI: Analytical and behavioural characterization of 1-cyclopropanoyl-d-lysergic acid diethylamide (1CP-LSD)

    Brandt, S. D., Kavanagh, P. V., Westphal, F., Stratford, A., Odland, Anna Ulstein, Klein, A. K., Dowling, G., Dempster, N. M., Wallach, J., Passie, T. & Halberstadt, A. L., 2020, In: Drug Testing and Analysis. 12, p. 812-826

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Diet Modulates the High Sensitivity to Systemic Infection in Newborn Preterm Pigs

    Bæk, Ole, Brunse, Anders, Nguyen, Duc Ninh, Moodley, Arshnee, Thymann, Thomas & Sangild, Per Torp, 2020, In: Frontiers in Immunology. 11, 14 p., 1019.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Impaired Neonatal Immunity and Infection Resistance Following Fetal Growth Restriction in Preterm Pigs

    Bæk, Ole, Ren, S., Brunse, Anders, Sangild, Per Torp & Nguyen, Duc Ninh, 2020, In: Frontiers in Immunology. 11, 1808.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Malnutrition predisposes to endotoxin-induced edema and impaired inflammatory response in parenterally fed piglets

    Bæk, Ole, Fabiansen, C., Friis, Henrik, Ritz, C., Koch, Jørgen, Willesen, Jakob, Heegaard, P. M. H., Lykkesfeldt, Jens, Briend, A., Golden, M. H., Sangild, Per Torp & Thymann, Thomas, 2020, In: Journal of Parenteral and Enteral Nutrition. 44, 4, p. 668-676

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Gabor patterns as stimuli in a rodent visual attention task

    Caballero-Puntiverio, M., Prichardt, S., Klem, Louise Bomholt, Bundesen, C., Vangkilde, Signe & Andreasen T., Jesper, 2020, In: Neuroscience Letters. 728, 8 p., 134970.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Hair glucocorticoids are not a historical marker of stress: exploring the time-scale of corticosterone incorporation into hairs in a rat model

    Colding-Jørgensen, Pernille, Hestehave, Sara, Abelson, Klas & Kalliokoski, O., 2020, bioRxiv, 21 p.

    Research output: Working paper › Preprint › Research

  29. Published

    Betamethasone Treatment for Atopic Dermatitis in Gut Microbiota Transplanted Mice

    Debes, Karina Poulsdóttir, Evdina, N. A., Laigaard, A., Larsen, J. M., Zachariassen, L. F., Hansen, Camilla Hartmann Friis & Hansen, Axel Kornerup, 2020, In: Comparative Medicine. 70, 1, p. 6-15 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Organomodified nanoclays induce less inflammation, acute phase response, and genotoxicity than pristine nanoclays in mice lungs

    di Ianni, Emilio, Møller, Peter, Mortensen, A., Szarek, J., Clausen, P. A., Saber, A. T., Vogel, U. & Jacobsen, N. R., 2020, In: Nanotoxicology. 14, 7, p. 869-892 24 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Subcutaneous Administration of Insulin is Associated With Regional Differences in Injection Depot Variability and Kinetics in The Rat

    Gradel, Anna Katrina Jógvansdóttir, Porsgaard, T., Lykkesfeldt, Jens, Brockhoff, P. M. B., Seested, T. & Refsgaard, H. H. F., 2020, In: Experimental and Clinical Endocrinology and Diabetes. 128, 5, p. 332-338 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    The counterregulatory response to hypoglycaemia in the pig

    Gradel, Anna Katrina Jógvansdóttir, Kildegaard, J., Ludvigsen, T. P., Porsgaard, T., Schou-Pedersen, A. M. V., Fels, J. J., Lykkesfeldt, Jens & Refsgaard, H. H. F., Oct 2020, In: Basic & Clinical Pharmacology & Toxicology. 127, 4, p. 278-286

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    The selective 5-HT2A receptor agonist 25CN-NBOH: structure-activity relationship, in vivo pharmacology, and in vitro and ex vivo binding characteristics of [3H]25CN-NBOH

    Jensen, Anders A., Halberstadt, A. L., Marcher, Emil, Odland, Anna Ulstein, Chatha, M., Speth, N., Liebscher, G., Hansen, M., Bräuner, Hans, Palner, M., Andreasen T., Jesper & Kristensen, Jesper Langgaard, 2020, In: Biochemical Pharmacology. 177, 16 p., 113979.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Variation in diagnostic NAFLD/NASH read-outs in paired liver samples from rodent models

    Jensen, Victoria Svop, Tveden-Nyborg, Pernille, Zacho-Rasmussen, C., Quaade, Michelle Lauge, Ipsen, David Højland, Hvid, H., Fledelius, C., Wulff, E. M. & Lykkesfeldt, Jens, 2020, In: Journal of Pharmacological and Toxicological Methods. 101, 9 p., 106651.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Inner histopathologic changes and disproportionate zone volumes in foetal growth plates following gestational hypoglycaemia in rats

    Jensen, Vivi Flou Hjorth, Mølck, A., Bøgh, I. B., Nowak, J., Viuff, B. M., Rasmussen, C. L. M., Voetmann, Louise Marie, Fels, J. J., Madsen, S. H., McGuigan, F. E., Tveden-Nyborg, Pernille, Lykkesfeldt, Jens & Akesson, K. E., 2020, In: Scientific Reports. 10, 1, 13 p., 5609.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    A novel derivative of thioridazine shows low toxicity and efficient activity against gram‐positive pathogens

    Jørgensen, N. S., Saaby, Lasse, Andersson, A. M., Kromann, Sofie, Sheikhsamani, E., Permin, A., Ronco, T., Svenningsen, Søren Wedel, Christensen, Jørn Bolstad & Olsen, Rikke Heidemann, 2020, In: Antibiotics. 9, 6, 11 p., 327.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Imiquimod does not elicit inflammatory responses in the skin of the naked mole rat (Heterocephalus glaber)

    Kisipan, Mosiany Letura, Ojoo, R. O., Kanui, T. I. & Abelson, Klas, 5 Sep 2020, In: BMC Research Notes. 13, 6 p., 416.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Dietary Intervention Accelerates NASH Resolution Depending on Inflammatory Status with Minor Additive Effects on Hepatic Injury by Vitamin E Supplementation

    Klaebel, J. H., Rakipovski, G., Andersen, B., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2020, In: Antioxidants. 9, 9, 808.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Receptor Activator of Nuclear Factor kappa-B Ligand is Not Regulated During Chronic Osteomyelitis in Pigs

    Lüthje, F. L., Skovgaard, K., Jensen, Henrik Elvang, Blirup-Plum, Sophie Amalie, Henriksen, Nicole Lind, Aalbæk, Bent & Jensen, Louise Kruse, 2020, In: Journal of Comparative Pathology. 179, p. 7-24 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Investigation of noradrenergic receptor system in anti-nociception using formalin test in the naked mole rat (Heterocephalus glaber)

    Mwobobia, Royford, Kanui, T. I. & Abelson, Klas, Oct 2020, In: Heliyon. 6, 10, 6 p., e05216.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Housing behaviour of the naked mole rat (Heterocephalus glaber) under laboratory conditions

    Mwobobia, Royford, Abelson, Klas & Kanui, T. I., 2020, In: Scandinavian Journal of Laboratory Animal Science. 46, 1, p. 16-24 9 p., 2.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Alpha-Lactalbumin Enriched Whey Protein Concentrate to Improve Gut, Immunity and Brain Development in Preterm Pigs

    Nielsen, Charlotte Holme, Hui, Y., Nguyen, Duc Ninh, Ahnfeldt, Agnethe May, Burrin, D. G., Hartmann, Bolette, Heckmann, A. B., Sangild, Per Torp, Thymann, Thomas & Bering, S. B., 2020, In: Nutrients. 12, 1, 20 p., 245.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Anthelmintic and metabolomic analyses of chicory (Cichorium intybus) identify an industrial by-product with potent in vitro antinematodal activity

    Peña-Espinoza, M., Valente, Angela Hørdum, Bornancin, L., Simonsen, H. T., Thamsborg, Stig Milan, Williams, Andrew Richard & López-Muñoz, R., 2020, In: Veterinary Parasitology. 280, 109088.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Polymorphisms in the serotonin transporter gene do not associate with myxomatous mitral valve disease or circulating serotonin levels in Cavalier King Charles Spaniels

    Reimann, Maria Josefine, 2020.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  45. Published

    A Novel Promazine Derivative Shows High in vitro and in vivo Antimicrobial Activity Against Staphylococcus aureus

    Ronco, T., Jørgensen, N. S., Holmer, I., Kromann, Sofie, Sheikhsamani, E., Permin, A., Svenningsen, Søren Wedel, Christensen, Jørn Bolstad & Olsen, Rikke Heidemann, 2020, In: Frontiers in Microbiology. 11, 12 p., 560798.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    TL1A regulates adipose-resident innate lymphoid immune responses and enables diet-induced obesity in mice

    Tougaard, P., Martinsen, L. O., Lützhøft, Ditte Olsen, Jensen, Henrik Elvang, Flethøj, M., Vandenabeele, P., Pedersen, Anders Elm, Skov, Søren, Hansen, Axel Kornerup & Hansen, Camilla Hartmann Friis, 2020, In: International journal of obesity (2005). 44, p. 1062–1074

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Central control of energy balance by amylin and calcitonin receptor agonists and their potential for treatment of metabolic diseases

    Zakariassen, Hannah Louise, John, L. M. & Lutz, T. A., 2020, In: Basic & Clinical Pharmacology & Toxicology. 127, 3, p. 163-177

    Research output: Contribution to journal › Review › Research › peer-review

  48. Published

    Salmon calcitonin distributes into the arcuate nucleus to a subset of NPY neurons in mice

    Zakariassen, Hannah Louise, John, L. M., Lykkesfeldt, Jens, Raun, K., Glendorf, T., Schaffer, L., Lundh, S., Secher, A., Lutz, T. A. & Le Foll, C., 2020, In: Neuropharmacology. 167, 107987.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. 2019
  50. Published

    FortiColos - A multicentre study using bovine colostrum as a fortifier to human milk in very preterm infants: Study protocol for a randomised controlled pilot trial

    Ahnfeldt, Agnethe May, Hyldig, N., Li, Y., Kappel, S. S., Aunsholdt, L., Sangild, Per Torp & Zachariassen, G., 2019, In: Trials. 20, 9 p., 279.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    Health effects of exposure to diesel exhaust in diesel-powered trains

    Andersen, M. H. G., Frederiksen, M., Saber, A. T., Wils, Regitze Sølling, Fonseca, A. S., Koponen, I. K., Johannesson, S., Roursgaard, Martin, Loft, Steffen, Møller, Peter & Vogel, U., 2019, In: Particle and Fibre Toxicology. 16, 14 p., 21.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. Published

    Growth Restriction and Systemic Immune Development in Preterm Piglets

    Bæk, Ole, Sangild, Per Torp, Thymann, Thomas & Nguyen, Duc Ninh, 2019, In: Frontiers in Immunology. 10, 2402.

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. Published

    Amylopectin Chain Length Dynamics and Activity Signatures of Key Carbon Metabolic Enzymes Highlight Early Maturation as Culprit for Yield Reduction of Barley Endosperm Starch after Heat Stress

    Cuesta-Seijo, J. A., De Porcellinis, A. J., Valente, Angela Hørdum, Striebeck, A., Voss, C., Marri, L., Hansson, A., Jansson, A. M., Dinesen, M. H., Fangel, J. U., Harholt, J., Popovic, M., Thieme, M., Hochmuth, A., Zeeman, S. C., Mikkelsen, T. N., Jørgensen, R. B., Roitsch, Thomas Georg, Møller, Birger Lindberg & Braumann, I., 2019, In: Plant and Cell Physiology. 60, 12, p. 2692-2706 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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