The Graduate Programme for In Vivo Pharmacology and Experimental Animals

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  1. Published

    Vasomotor function in rat arteries after ex vivo and intragastric exposure to food-grade titanium dioxide and vegetable carbon particles

    Jensen, Ditte Marie, Christophersen, D. V., Sheykhzade, Majid, Skovsted, Gry Freja, Lykkesfeldt, Jens, Münter, R., Roursgaard, Martin, Loft, Steffen & Møller, Peter, 26 Feb 2018, In: Particle and Fibre Toxicology. 15, p. 1-18 12.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Vasomotor dysfunction in human subcutaneous arteries exposed ex vivo to food-grade titanium dioxide

    Jensen, Ditte Marie, Skovsted, Gry Freja, Lykkesfeldt, Jens, Dreier, R., Berg, J. O., Jeppesen, J. L., Sheykhzade, Majid, Loft, Steffen & Møller, Peter, 2018, In: Food and Chemical Toxicology. 120, p. 321-327 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Guideline for Preclinical Studies of Bone Infections in Large Animals Based on a Systematic Review of 316 Non-Rodent Models

    Jensen, Louise Kruse, Henriksen, Nicole Lind, Blirup-Plum, Sophie Amalie & Jensen, Henrik Elvang, 2019, In: The Journal of bone and joint surgery. American volume. 101, 21, p. 1894-1903 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Guidelines for porcine models of human bacterial infections

    Jensen, Louise Kruse, Henriksen, Nicole Lind & Jensen, Henrik Elvang, 2019, In: Laboratory Animals. 53, 2, p. 125-136

    Research output: Contribution to journal › Review › Research › peer-review

  5. Published

    In vivo gentamicin susceptibility test for prevention of bacterial biofilms in bone tissue and on implants

    Jensen, Louise Kruse, Bjarnsholt, Thomas, Kragh, K. N., Aalbæk, Bent, Henriksen, Nicole Lind, Blirup-Plum, Sophie Amalie, Pankoke, K., Petersen, A. & Jensen, Henrik Elvang, 2019, In: Antimicrobial Agents and Chemotherapy. 63, 2, 10 p., e01889-18.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Guideline for preclinical studies of bone infections

    Jensen, Louise Kruse, Henriksen, Nicole Lind, Blirup-Plum, Sophie Amalie & Jensen, Henrik Elvang, 12 Sep 2019.

    Research output: Contribution to conference › Conference abstract for conference › Communication

  7. Published

    Systematic review of 316 animal models of bone infections - a call for improved quality

    Jensen, Louise Kruse, Henriksen, Nicole Lind, Blirup-Plum, Sophie Amalie & Jensen, Henrik Elvang, 21 Mar 2019.

    Research output: Contribution to conference › Conference abstract for conference › Communication

  8. Published

    Variation in diagnostic NAFLD/NASH read-outs in paired liver samples from rodent models

    Jensen, Victoria Svop, Tveden-Nyborg, Pernille, Zacho-Rasmussen, C., Quaade, Michelle Lauge, Ipsen, David Højland, Hvid, H., Fledelius, C., Wulff, E. M. & Lykkesfeldt, Jens, 2020, In: Journal of Pharmacological and Toxicological Methods. 101, 9 p., 106651.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Dietary fat stimulates development of NAFLD more potently than dietary fructose in Sprague-Dawley rats

    Jensen, Victoria Svop, Hvid, H., Damgaard, J., Nygaard, H., Ingvorsen, C., Wulff, E. M., Lykkesfeldt, Jens & Fledelius, C., 2018, In: Diabetology and Metabolic Syndrome. 10, 13 p., 4.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Rodent model choice has major impact on variability of standard preclinical readouts associated with diabetes and obesity research

    Jensen, Victoria Svop, Porsgaard, T., Lykkesfeldt, Jens & Hvid, H., 15 Aug 2016, In: American Journal of Translational Research. 8, 8, p. 3574-3584

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Insulin treatment improves liver histopathology and decreases expression of inflammatory and fibrogenic genes in a hyperglycemic, dyslipidemic hamster model of NAFLD

    Jensen, Victoria Svop, Fledelius, C., Zachodnik, C., Damgaard, J., Nygaard, H., Tornqvist, K. S., Kirk, R. K., Viuff, B. M., Wulff, E. M., Lykkesfeldt, Jens & Hvid, H., 2021, In: Journal of Translational Medicine. 19, 1, 80.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Temporal development of dyslipidemia and nonalcoholic fatty liver disease (Nafld) in syrian hamsters fed a high‐fat, high‐fructose, high‐cholesterol diet

    Jensen, Victoria Svop, Fledelius, C., Wulff, E. M., Lykkesfeldt, Jens & Hvid, H., 2021, In: Nutrients. 13, 2, p. 1-18 18 p., 604.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Inner histopathologic changes and disproportionate zone volumes in foetal growth plates following gestational hypoglycaemia in rats

    Jensen, Vivi Flou Hjorth, Mølck, A., Bøgh, I. B., Nowak, J., Viuff, B. M., Rasmussen, C. L. M., Voetmann, Louise Marie, Fels, J. J., Madsen, S. H., McGuigan, F. E., Tveden-Nyborg, Pernille, Lykkesfeldt, Jens & Akesson, K. E., 2020, In: Scientific Reports. 10, 1, 13 p., 5609.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    A novel derivative of thioridazine shows low toxicity and efficient activity against gram‐positive pathogens

    Jørgensen, N. S., Saaby, Lasse, Andersson, A. M., Kromann, Sofie, Sheikhsamani, E., Permin, A., Ronco, T., Svenningsen, Søren Wedel, Christensen, Jørn Bolstad & Olsen, Rikke Heidemann, 2020, In: Antibiotics. 9, 6, 11 p., 327.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    A Randomized, Controlled Study to Investigate How Bovine Colostrum Fortification of Human Milk Affects Bowel Habits in Preterm Infants (FortiColos Study)

    Kappel, S. S., Sangild, Per Torp, Ahnfeldt, Agnethe May, Johannsdottir, V., Soernsen, L. J., Bak, L. B., Friborg, C., Moller, S., Zachariassen, G. & Aunsholt, Lise, 2022, In: Nutrients. 14, 22, 14 p., 4756.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Perioperative nivolumab monotherapy versus nivolumab plus ipilimumab in resectable hepatocellular carcinoma: a randomised, open-label, phase 2 trial

    Kaseb, A. O., Hasanov, E., Cao, H. S. T., Xiao, L., Vauthey, J. N., Lee, S. S., Yavuz, B. G., Mohamed, Y. I., Qayyum, A., Jindal, S., Duan, F., Basu, S., Yadav, S. S., Nicholas, C., Sun, J. J., Singh Raghav, K. P., Rashid, A., Carter, K., Chun, Y. S., Tzeng, C. W. D. & 9 others, Sakamuri, D., Xu, L., Sun, R., Cristini, V., Beretta, L., Yao, J. C., Wolff, R. A., Allison, J. P. & Sharma, P., 2022, In: The Lancet Gastroenterology and Hepatology. 7, 3, p. 208-218 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Imiquimod does not elicit inflammatory responses in the skin of the naked mole rat (Heterocephalus glaber)

    Kisipan, Mosiany Letura, Ojoo, R. O., Kanui, T. I. & Abelson, Klas, 5 Sep 2020, In: BMC Research Notes. 13, 6 p., 416.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Bodyweight, locomotion, and behavioral responses in the naked mole-rat (heterocephalus glaber) after lipopolysaccharide administration

    Kisipan, Mosiany Letura, Ojoo, R. O., Kanui, T. I. & Abelson, Klas, 2022, In: Laboratory Animals. 56, S1, p. 191-191 PE21.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  19. Published

    Dietary Intervention Accelerates NASH Resolution Depending on Inflammatory Status with Minor Additive Effects on Hepatic Injury by Vitamin E Supplementation

    Klaebel, J. H., Rakipovski, G., Andersen, B., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2020, In: Antioxidants. 9, 9, 808.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Atorvastatin and vitamin e accelerates NASH resolution by dietary intervention in a preclinical guinea pig model

    Klaebel, J. H., Skjødt, M., Skat-Rørdam, Josephine, Rakipovski, G., Ipsen, David Højland, Schou-Pedersen, A. M. V., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2019, In: Nutrients. 11, 11, 20 p., 2834.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Efficacy of fibroblast growth factor 21 in non-alcoholic fatty liver disease in guinea pigs

    Klaebel, J. H., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2022, In: Basic & Clinical Pharmacology & Toxicology. 130, 3, p. 385-393

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Alcohol-related breast cancer in postmenopausal women - effect of CYP19A1, PPARG and PPARGC1A polymorphisms on female sex-hormone levels and interaction with alcohol consumption and NSAID usage in a nested case-control study and a randomised controlled trial

    Kopp, T. I., Jensen, Ditte Marie, Ravn-Haren, G., Cohen, A., Sommer, H. M., Dragsted, Lars Ove, Tjønneland, A., Hougaard, D. M. & Vogel, U., 2016, In: BMC Cancer. 16, 19 p., 283.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Pharmacological safety of dimethoxy curcumin-human serum albumin conjugate for potential therapeutic purpose

    Korah, M. C., Sreelatha, Harikrishnan Vijayakumar, Deepa, S., Arya, A., Sabareeswaran, A., Mohanan, P. V. & Krishnan, L. K., 2023, In: Canadian Journal of Physiology and Pharmacology. 101, 6, p. 304-315

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Hemostatic parameters in preterm and full-term pigs of identical postnatal age

    Krogh, Anne Kirstine Havnsøe, Brunse, Anders, Thymann, Thomas, Bochsen, L. & Kristensen, Annemarie T., 20 Oct 2018.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  25. Published

    Dramatic increase in slaughter condemnations due to Escherichia coli ST23 and ST101 within the Danish broiler production

    Kromann, Sofie, Baig, S., Olsen, Rikke Heidemann, Edslev, S. M., Thoefner, Ida , Bojesen, Anders Miki, Jensen, Henrik Elvang & Stegger, M., 2023, In: Veterinary Microbiology. 280, 109696.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Establishment and application of an aerogenous model of avian colibacillosis

    Kromann, Sofie, Olsen, Rikke Heidemann, Bojesen, Anders Miki, Thoefner, Ida & Jensen, Henrik Elvang, 2023.

    Research output: Contribution to conference › Conference abstract for conference › Communication

  27. Published

    Protective potential of an autogenous vaccine in an aerogenous model of escherichia coli infection in broiler breeders

    Kromann, Sofie, Olsen, Rikke Heidemann, Bojesen, Anders Miki, Jensen, Henrik Elvang & Thoefner, Ida , 2021, In: Vaccines. 9, 11, 1233.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Development of an aerogenous Escherichia coli infection model in adult broiler breeders

    Kromann, Sofie, Olsen, Rikke Heidemann, Bojesen, Anders Miki, Jensen, Henrik Elvang & Thoefner, Ida , 2021, In: Scientific Reports. 11, 15 p., 19556.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Colibacillosis in poultry: Aetiology, pathogenesis, diagnosis, and control

    Kromann, Sofie, 2022, University of Copenhagen.

    Research output: Book/Report › Ph.D. thesis › Research

  30. Published

    Assessment of automated assays for serum amyloid A, haptoglobin (PIT54) and basic biochemistry in broiler breeders experimentally infected with Escherichia coli

    Kromann, Sofie, Olsen, Rikke Heidemann, Bojesen, Anders Miki, Jensen, Henrik Elvang & Thoefner, Ida , 2022, In: Veterinary Research. 53, 1, 7 p., 25.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    In vivo models of Escherichia coli infection in poultry

    Kromann, Sofie & Jensen, Henrik Elvang, 2022, In: Acta Veterinaria Scandinavica. 64, 33.

    Research output: Contribution to journal › Review › Research › peer-review

  32. Published

    In vitro synergy of sertraline and tetracycline cannot be reproduced in pigs orally challenged with a tetracycline resistant Escherichia coli

    Kromann, Sofie, Hvidtfeldt, A., Boye, M., Sørensen, Dorte Bratbo, Jørgensen, S., Nielsen, Jens Peter & Olsen, Rikke Heidemann, 2019, In: BMC Microbiology. 19, 1, 12 p., 12.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Longitudinal study on background lesions in broiler breeder flocks and their progeny, and genomic characterisation of Escherichia coli

    Kromann, Sofie, Baig, S., Stegger, M., Olsen, Rikke Heidemann, Bojesen, Anders Miki, Jensen, Henrik Elvang & Thoefner, Ida , 2022, In: Veterinary Research. 53, 52.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    A reduced CP level without medicinal zinc oxide does not alter the intestinal morphology in weaned pigs 24 days post-weaning

    Larsen, Christina, Lynegaard, J. C., Pedersen, Anni Øyan, Kjeldsen, N. J., Hansen, C. F., Nielsen, Jens Peter & Williams, Charlotte Amdi, 2021, In: Animal. 15, 4, 100188.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Transplantation of fecal filtrate to neonatal pigs reduces post-weaning diarrhea: A pilot study

    Larsen, Christina, Andersen, A. B., Sato, Helena, Brunse, Anders & Thymann, Thomas, 2023, In: Frontiers in Veterinary Science. 10, 12 p., 1110128.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Effects of early postnatal gastric and colonic microbiota transplantation on piglet gut health

    Larsen, Christina, Offersen, Simone Margaard, Brunse, Anders, Pirolo, Mattia, Kar, S. K., Guadabassi, L. & Thymann, Thomas, 2023, In: Journal of Animal Science and Biotechnology. 14, 14 p., 158.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Pasteurization Procedures for Donor Human Milk Affect Body Growth, Intestinal Structure, and Resistance against Bacterial Infections in Preterm Pigs

    Li, Y., Nguyen, Duc Ninh, de Waard, M., Christensen, Lars, Zhou, P., Jiang, Pingping, Sun, Jing, Bojesen, Anders Miki, Lauridsen, C., Lykkesfeldt, Jens, Dalsgaard, T. K., Bering, S. B. & Sangild, Per Torp, Jun 2017, In: Journal of Nutrition. 147, 6, p. 1121-1130

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Antibiotic Resistance of Lactobacillus spp. and Streptococcus thermophilus Isolated from Chinese Fermented Milk Products

    Li, Y., Li, L., Kromann, Sofie, Chen, M., Shi, L. & Meng, H., 2019, In: Foodborne pathogens and disease. 16, 3, p. 221-228

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    An Oligosaccharide Rich Diet Increases Akkermansia spp. Bacteria in the Equine Microbiota

    Lindenberg, F. C., Lützhøft, Ditte Olsen, Krych, Lukasz, Fielden, J., Kot, Witold, Frøkiær, Hanne, van Galen, G., Nielsen, Dennis Sandris & Hansen, Axel Kornerup, 2021, In: Frontiers in Microbiology. 12, 666039.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. E-pub ahead of print

    Validation of computed tomography as a diagnostic tool in guinea pigs with non-alcoholic fatty liver disease

    Lintrup, K., Ipsen, David Højland, Skat-Rørdam, Josephine, Lykkesfeldt, Jens, Tveden-Nyborg, Pernille & Buelund, Lene Elisabeth, 2024, (E-pub ahead of print) In: Laboratory Animals.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    An increased weaning age and liquid feed enhances weight gain compared to piglets fed dry feed pre-weaning

    Lyderik, Kimmie Kyed, Madsen, Johannes Gulmann, Larsen, Christina, Pedersen, M. L. M., Kjeldsen, N. J., Williams, Andrew Richard, Hedemann, M. S. & Williams, Charlotte Amdi, 2023, In: Animal. 17, 5, 100801.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Effects of Weaning Age and Creep Feed Type on Growth Performance and Gut Maturation in Weaned Piglets

    Lyderik, Kimmie Kyed, Zhang, X., Larsen, Christina, Kjeldsen, N. J., Pedersen, M. L. M., Hedemann, M. S., Williams, Andrew Richard, Williams, Charlotte Amdi & Madsen, Johannes Gulmann, 2023, In: Animals. 13, 11, 1851.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Hyperinsulinaemic hypoglycaemia in non-anaesthetized Göttingen minipigs induces a counter-regulatory endocrine response and electrocardiographic changes

    Lyhne, Mille Kronborg, Vegge, A., Povlsen, G. K., Slaaby, R., Kildegaard, J., Pedersen-Bjergaard, Ulrik & Olsen, Lisbeth Høier, 2021, In: Scientific Reports. 11, 11 p., 5983.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Electrocardiography and heart rate variability in Göttingen Minipigs: Impact of diurnal variation, lead placement, repeatability and streptozotocin-induced diabetes

    Lyhne, Mille Kronborg, Debes, Karina Poulsdóttir, Helgogaard, T., Vegge, A., Kildegaard, J., Pedersen-Bjergaard, Ulrik & Olsen, Lisbeth Høier, 2022, In: Journal of Pharmacological and Toxicological Methods. 118, 107221.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Receptor Activator of Nuclear Factor kappa-B Ligand is Not Regulated During Chronic Osteomyelitis in Pigs

    Lüthje, F. L., Skovgaard, K., Jensen, Henrik Elvang, Blirup-Plum, Sophie Amalie, Henriksen, Nicole Lind, Aalbæk, Bent & Jensen, Louise Kruse, 2020, In: Journal of Comparative Pathology. 179, p. 7-24 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Marked gut microbiota dysbiosis and increased imidazole propionate are associated with a NASH Göttingen Minipig model

    Lützhøft, Ditte Olsen, Sinioja, T., Christoffersen, B., Jakobsen, Rasmus Riemer, Geng, Dawei, Ahmad, H. F. B., Straarup, E. M., Pedersen, K. M., Kot, Witold, Pedersen, H. D., Cirera, Susanna, Hyötyläinen, T., Nielsen, Dennis Sandris & Hansen, Axel Kornerup, 2022, In: BMC Microbiology. 22, 1, 287.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Short communication: Gut microbial colonization of the mouse colon using faecal transfer was equally effective when comparing rectal inoculation and oral inoculation based on 16S rRNA sequencing

    Lützhøft, Ditte Olsen, Sánchez-Alcoholado, L., Tougaard, P., Mentzel, Caroline M. Junker, Kot, Witold, Nielsen, Dennis Sandris & Hansen, Axel Kornerup, 2019, In: Research in Veterinary Science. 126, p. 227-232 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Training improves oxidative capacity, but not function, in spinal muscular atrophy type III

    Madsen, K. L., Wils, Regitze Sølling, Preisler, N., Thøgersen, F., Berthelsen, M. P. & Vissing, John, Aug 2015, In: Muscle & Nerve. 52, 2, p. 240–244 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Modulation of nociception by amitriptyline hydrochloride in the Speke’s hinge-back tortoise (Kiniskys spekii)

    Musembi Makau, Christopher, Towett, P. K., Abelson, Klas & Kanui, T. I., 2021, In: Veterinary Medicine and Science. 7, 3, p. 1034-1041

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Effects of inhibition of Nav1.3, Nav1.7, and Nav1.8 channels on pain-related behavior in Speke's hinge-back tortoise (Kinixys spekii)

    Musembi Makau, Christopher, Towett, P. K., Kanui, T. I. & Abelson, Klas, 2024, In: Journal of Neuroscience Research. 102, 1, e25274.

    Research output: Contribution to journal › Journal article › Research › peer-review

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