The Graduate Programme for In Vivo Pharmacology and Experimental Animals

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  1. Published

    [68Ga]Ga-NODAGA-E[(cRGDyK)]2 Angiogenesis PET/MR in a Porcine Model of Chronic Myocardial Infarction

    Bentsen, Simon, Clemmensen, Andreas Høeg, Loft, Mathias Hougaard, Flethøj, M., Debes, Karina Poulsdóttir, Ludvigsen, Trine Pagh, Larsen, C. B., Kirchhoff, J., Olsen, Lisbeth Høier, Møller, J. E., Andersen, Thomas Lund, Johannesen, Helle Hjorth, Jespersen, Thomas & Kjær, Andreas, 2021, In: Diagnostics. 11, 10, 1807.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    We need to talk about fraudulent animal studies: learnings from a systematic review

    Berrio Sanchez, Jenny Paola & Kalliokoski, Otto, 2022, In: Laboratory Animals. 56, S1, p. 172-172 PD15.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  3. Published

    Vitamin C deficiency may delay diet-induced NASH regression in the guinea pig

    Skat-Rørdam, Josephine, Pedersen, Kamilla, Skovsted, Gry Freja, Gregersen, I., Vangsgaard, S., Ipsen, David Højland, Latta, M., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2022, In: Antioxidants. 11, 1, 69.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Vitamin C Deficiency Exacerbates Dysfunction of Atherosclerotic Coronary Arteries in Guinea Pigs Fed a High-Fat Diet

    Skovsted, Gry Freja, Skat-Rørdam, Josephine, Frøkiær, A. P., Jensen, Henrik Elvang, Tveden-Nyborg, Pernille & Lykkesfeldt, Jens, 2022, In: Antioxidants. 11, 11, 2226.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Vasomotor function in rat arteries after ex vivo and intragastric exposure to food-grade titanium dioxide and vegetable carbon particles

    Jensen, Ditte Marie, Christophersen, D. V., Sheykhzade, Majid, Skovsted, Gry Freja, Lykkesfeldt, Jens, Münter, R., Roursgaard, Martin, Loft, Steffen & Møller, Peter, 26 Feb 2018, In: Particle and Fibre Toxicology. 15, p. 1-18 12.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Vasomotor dysfunction in human subcutaneous arteries exposed ex vivo to food-grade titanium dioxide

    Jensen, Ditte Marie, Skovsted, Gry Freja, Lykkesfeldt, Jens, Dreier, R., Berg, J. O., Jeppesen, J. L., Sheykhzade, Majid, Loft, Steffen & Møller, Peter, 2018, In: Food and Chemical Toxicology. 120, p. 321-327 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Vascular and lung function related to ultrafine and fine particles exposure assessed by personal and indoor monitoring: a cross-sectional study

    Olsen, Y., Karottki, D. G., Jensen, Ditte Marie, Bekö, G., Kjeldsen, B. U., Clausen, G., Hersoug, L., Holst, G. J., Wierzbicka, A., Sigsgaard, T., Linneberg, Allan René, Møller, Peter & Loft, Steffen, 2014, In: Environmental Health. 13, p. 1-10 10 p., 112.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Variation in diagnostic NAFLD/NASH read-outs in paired liver samples from rodent models

    Jensen, Victoria Svop, Tveden-Nyborg, Pernille, Zacho-Rasmussen, C., Quaade, Michelle Lauge, Ipsen, David Højland, Hvid, H., Fledelius, C., Wulff, E. M. & Lykkesfeldt, Jens, 2020, In: Journal of Pharmacological and Toxicological Methods. 101, 9 p., 106651.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. E-pub ahead of print

    Validation of computed tomography as a diagnostic tool in guinea pigs with non-alcoholic fatty liver disease

    Lintrup, K., Ipsen, David Højland, Skat-Rørdam, Josephine, Lykkesfeldt, Jens, Tveden-Nyborg, Pernille & Buelund, Lene Elisabeth, 2024, (E-pub ahead of print) In: Laboratory Animals.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Ultra-High Temperature Treatment of Liquid Infant Formula, Systemic Immunity, and Kidney Development in Preterm Neonates

    Sun, Jing, Akıllıoğlu, H. G., Zhong, Jingren, Muk (Mudi), Tik, Pan, X., Lund, Marianne N., Sangild, Per Torp, Nguyen, Duc Ninh & Bering, S. B., 2023, In: Molecular Nutrition and Food Research. 67, 24, 12 p., 2300318.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Ultra-High Temperature Treatment and Storage of Infant Formula Induces Dietary Protein Modifications, Gut Dysfunction, and Inflammation in Preterm Pigs

    Sun, Jing, Akıllıoğlu, H. G., Aasmul-Olsen, Karoline, Ye, Y., Lund, P., Zhao, X., Brunse, Anders, Nielsen, C. F., Chatterton, Dereck Edward Winston, Sangild, Per Torp, Lund, Marianne N. & Bering, S. B., 2022, In: Molecular Nutrition & Food Research. 66, 20, 13 p., 2200132.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Transplantation of fecal filtrate to neonatal pigs reduces post-weaning diarrhea: A pilot study

    Larsen, Christina, Andersen, A. B., Sato, Helena, Brunse, Anders & Thymann, Thomas, 2023, In: Frontiers in Veterinary Science. 10, 12 p., 1110128.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Training improves oxidative capacity, but not function, in spinal muscular atrophy type III

    Madsen, K. L., Wils, Regitze Sølling, Preisler, N., Thøgersen, F., Berthelsen, M. P. & Vissing, John, Aug 2015, In: Muscle & Nerve. 52, 2, p. 240–244 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    The selective 5-HT2A receptor agonist 25CN-NBOH does not affect reversal learning in mice

    Odland, Anna Ulstein, Kristensen, Jesper Langgaard & Andreasen T., Jesper, 2021, In: Behavioural Pharmacology. 32, 5, p. 448-452

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    The selective 5-HT2A receptor agonist 25CN-NBOH: structure-activity relationship, in vivo pharmacology, and in vitro and ex vivo binding characteristics of [3H]25CN-NBOH

    Jensen, Anders A., Halberstadt, A. L., Marcher, Emil, Odland, Anna Ulstein, Chatha, M., Speth, N., Liebscher, G., Hansen, M., Bräuner, Hans, Palner, M., Andreasen T., Jesper & Kristensen, Jesper Langgaard, 2020, In: Biochemical Pharmacology. 177, 16 p., 113979.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    The intestinal permeability marker FITC-dextran 4kDa should be dosed according to lean body mass in obese mice

    Voetmann, Louise Marie, Rolin, B., Kirk, R. K., Pyke, C. & Hansen, Axel Kornerup, 2023, In: Nutrition and Diabetes. 13, 1.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    The impact of exercise training and resveratrol supplementation on gut microbiota composition in high-fat diet fed mice

    Brandt, N., Kotowska, D., Kristensen, C. M., Olesen, J., Lützhøft, Ditte Olsen, Halling, Jens Frey, Hansen, M., Al-Soud, W. A., Hansen, Lars Hestbjerg, Kiilerich, P. & Pilegaard, Henriette, 2018, In: Physiological Reports. 6, 20, p. 1-11 e13881.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    The effect of feeding liquid or dry creep feed on growth performance, feed disappearance, enzyme activity and number of eaters in suckling piglets

    Byrgesen, N., Madsen, Johannes Gulmann, Larsen, Christina, Kjeldsen, N. J., Cilieborg, Malene Skovsted & Williams, Charlotte Amdi, 2021, In: Animals. 11, 11, 3144.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    The effect of acetylsalicylic acid and pentoxifylline in guinea pigs with non-alcoholic steatohepatitis

    Ipsen, David Højland, Skat-Rørdam, Josephine, Svenningsen, M., Andersen, Mia Trein, Latta, M., Buelund, Lene Elisabeth, Lintrup, K., Skaarup, R., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2021, In: Basic & Clinical Pharmacology & Toxicology. 128, 4, p. 583-593

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    The development of nonalcoholic steatohepatitis is subjected to breeder dependent variation in guinea pigs

    Ipsen, David Højland, Agerskov, R. H., Klaebel, J. H., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2021, In: Scientific Reports. 11, 2955.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    The counterregulatory response to hypoglycaemia in the pig

    Gradel, Anna Katrina Jógvansdóttir, Kildegaard, J., Ludvigsen, T. P., Porsgaard, T., Schou-Pedersen, A. M. V., Fels, J. J., Lykkesfeldt, Jens & Refsgaard, H. H. F., Oct 2020, In: Basic & Clinical Pharmacology & Toxicology. 127, 4, p. 278-286

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    The adjuvant-induced rat model of monoarthritis: welfare implications and possible refinement strategies

    Berke, M. S. & Abelson, Klas, 2020, In: Scandinavian Journal of Laboratory Animal Science. 46, 5, p. 39-50 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    The G213D variant in Nav1.5 alters sodium current and causes an arrhythmogenic phenotype resulting in a multifocal ectopic Purkinje-related premature contraction phenotype in human-induced pluripotent stem cell-derived cardiomyocytes

    Callø, Kirstine, Geryk, M., Freude, Kristine, Treat, J. A., Vold, V. A., Frederiksen, Henriette Reventlow S, Broendberg, A. K., Frederiksen, T. C., Jensen, H. K. & Cordeiro, J. M., 2022, In: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 24, 12, p. 2015–2027

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Temporal development of dyslipidemia and nonalcoholic fatty liver disease (Nafld) in syrian hamsters fed a high‐fat, high‐fructose, high‐cholesterol diet

    Jensen, Victoria Svop, Fledelius, C., Wulff, E. M., Lykkesfeldt, Jens & Hvid, H., 2021, In: Nutrients. 13, 2, p. 1-18 18 p., 604.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Telomere length and genotoxicity in the lung of rats following intragastric exposure to food-grade titanium dioxide and vegetable carbon particles

    Jensen, Ditte Marie, Løhr, M., Sheykhzade, Majid, Lykkesfeldt, Jens, Wils, Regitze Sølling, Loft, Steffen & Møller, Peter, 2019, In: Mutagenesis. 34, 2, p. 203-214 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Telomere dynamics and cellular senescence: an emerging field in environmental and occupational toxicology

    Møller, Peter, Wils, Regitze Sølling, Jensen, Ditte Marie, Andersen, M. H. G. & Roursgaard, Martin, 2018, In: Critical Reviews in Toxicology. 48, 9, p. 761-788 28 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    TL1A regulates adipose-resident innate lymphoid immune responses and enables diet-induced obesity in mice

    Tougaard, P., Martinsen, L. O., Lützhøft, Ditte Olsen, Jensen, Henrik Elvang, Flethøj, M., Vandenabeele, P., Pedersen, Anders Elm, Skov, Søren, Hansen, Axel Kornerup & Hansen, Camilla Hartmann Friis, 2020, In: International journal of obesity (2005). 44, p. 1062–1074

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Systematic review of 316 animal models of bone infections - a call for improved quality

    Jensen, Louise Kruse, Henriksen, Nicole Lind, Blirup-Plum, Sophie Amalie & Jensen, Henrik Elvang, 21 Mar 2019.

    Research output: Contribution to conference › Conference abstract for conference › Communication

  29. Published

    Systematic review and meta-analysis of studies in which burrowing behaviour was assessed in rodent models of disease-associated persistent pain

    Zhang, X. Y., Barakat, Ahmed, Diaz-delCastillo, M., Vollert, J., Sena, E. S., Heegaard, Anne-Marie, Rice, A. S. C. & Soliman, N., 2022, In: Pain. 163, 11, p. 2076-2102

    Research output: Contribution to journal › Review › Research › peer-review

  30. Published

    Suckling Induces Differential Gut Enzyme Activity and Body Composition Compared to Feeding Milk Replacer in Piglets

    Williams, Charlotte Amdi, Pedersen, M. L. M., Larsen, Christina, Klaaborg, J., Williams, Andrew Richard & Madsen, Johannes Gulmann, 2022, In: Animals. 12, 22, 3112.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Subcutaneous Administration of Insulin is Associated With Regional Differences in Injection Depot Variability and Kinetics in The Rat

    Gradel, Anna Katrina Jógvansdóttir, Porsgaard, T., Lykkesfeldt, Jens, Brockhoff, P. M. B., Seested, T. & Refsgaard, H. H. F., 2020, In: Experimental and Clinical Endocrinology and Diabetes. 128, 5, p. 332-338 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Stability and development of psychotic symptoms and the use of antipsychotic medication - long-term follow-up

    Gotfredsen, D. R., Wils, Regitze Sølling, Hjorthøj, C., Austin, Stephen Fitzgerald, Albert, N., Secher, R. G., Thorup, Anne, Mors, O. & Nordentoft, Merete, Sep 2017, In: Psychological Medicine. 47, 12, p. 2118-2129 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Short communication: Gut microbial colonization of the mouse colon using faecal transfer was equally effective when comparing rectal inoculation and oral inoculation based on 16S rRNA sequencing

    Lützhøft, Ditte Olsen, Sánchez-Alcoholado, L., Tougaard, P., Mentzel, Caroline M. Junker, Kot, Witold, Nielsen, Dennis Sandris & Hansen, Axel Kornerup, 2019, In: Research in Veterinary Science. 126, p. 227-232 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Sex-Specific Survival, Growth, Immunity and Organ Development in Preterm Pigs as Models for Immature Newborns

    Bæk, Ole, Cilieborg, Malene Skovsted, Nguyen, Duc Ninh, Bering, S. B., Thymann, Thomas & Sangild, Per Torp, 2021, In: Frontiers in Pediatrics. 9, 12 p., 626101.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Semaglutide treatment attenuates vessel remodelling in ApoE−/− mice following vascular injury and blood flow perturbation

    Jensen, Ditte Marie, Skovsted, Gry Freja, Bonde, M. F. B., Bentzon, J. F., Rolin, B., Franck, G., Ougaard, M. K. E., Voetmann, Louise Marie, Bachmann, J. C., Uryga, A., Pyke, C., Kirk, R. K., Hvid, H., Knudsen, L. B., Lykkesfeldt, Jens & Nyberg, M., 2022, In: Atherosclerosis Plus. 49, p. 32-41 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Searching for assay controls for the Fpg- and hOGG1-modified comet assay

    Møller, Peter, Jantzen, K., Løhr, M., Andersen, M. H., Jensen, Ditte Marie, Roursgaard, Martin, Danielsen, P. H., Jensen, Annie & Loft, Steffen, 24 Feb 2018, In: Mutagenesis. 33, 1, p. 9-19 11 p.

    Research output: Contribution to journal › Review › Research › peer-review

  37. Published

    Salmon calcitonin distributes into the arcuate nucleus to a subset of NPY neurons in mice

    Zakariassen, Hannah Louise, John, L. M., Lykkesfeldt, Jens, Raun, K., Glendorf, T., Schaffer, L., Lundh, S., Secher, A., Lutz, T. A. & Le Foll, C., 2020, In: Neuropharmacology. 167, 107987.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Role of oxidative stress in carbon nanotube-generated health effects

    Møller, P., Christophersen, D. V., Jensen, Ditte Marie, Kermanizadeh, A., Roursgaard, Martin, Jacobsen, N. R., Hemmingsen, J. G., Danielsen, P. H., Cao, Y., Jantzen, K., Klingberg, H., Hersoug, L. & Loft, Steffen, Nov 2014, In: Archives of Toxicology. 88, 11, p. 1939-64 26 p.

    Research output: Contribution to journal › Review › Research › peer-review

  39. Published

    Rodent model choice has major impact on variability of standard preclinical readouts associated with diabetes and obesity research

    Jensen, Victoria Svop, Porsgaard, T., Lykkesfeldt, Jens & Hvid, H., 15 Aug 2016, In: American Journal of Translational Research. 8, 8, p. 3574-3584

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Return of the lysergamides. Part VI: Analytical and behavioural characterization of 1-cyclopropanoyl-d-lysergic acid diethylamide (1CP-LSD)

    Brandt, S. D., Kavanagh, P. V., Westphal, F., Stratford, A., Odland, Anna Ulstein, Klein, A. K., Dowling, G., Dempster, N. M., Wallach, J., Passie, T. & Halberstadt, A. L., 2020, In: Drug Testing and Analysis. 12, p. 812-826

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Rethinking data treatment: The sucrose preference threshold for anhedonia in stress-induced rat models of depression

    Berrio Sanchez, Jenny Paola & Kalliokoski, Otto, 2023, In: Journal of Neuroscience Methods. 395, 11 p., 109910.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Reliability of sucrose preference testing following short or no food and water deprivation—a Systematic Review and Meta-Analysis of rat models of chronic unpredictable stress

    Berrio Sanchez, Jenny Paola, Hestehave, Sara & Kalliokoski, Otto, 2024, In: Translational Psychiatry. 14, 1, 10 p., 39.

    Research output: Contribution to journal › Review › Research › peer-review

  43. Published

    Refinement of the spinal cord injury rat model and validation of its applicability as a model for memory loss and chronic pain

    Sreelatha, Harikrishnan Vijayakumar, Palekkodan, H., Fasaludeen, A., Krishnan, L. K. & Abelson, Klas, 2021, In: Heliyon. 7, 7, 11 p., e07500.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Refinement of the rat contusion model of thoracic spinal cord injury

    Sreelatha, Harikrishnan Vijayakumar, Palekkodan, H., Fasaludeen, A., Krishnan, L. K. & Abelson, Klas, 2022, In: Laboratory Animals. 56, S1, p. 27-27 S2B3.1.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  45. Published

    Refinement of the motorised laminectomy-assisted rat spinal cord injury model by analgesic treatment

    Sreelatha, Harikrishnan Vijayakumar, Palekkodan, H., Fasaludeen, A., Krishnan, L. K. & Abelson, Klas, 2024, In: PLoS ONE. 19, 1 , 23 p., e0294720.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Reduced early life mucosal integrity decreases thymic cell counts and increases local, but not thymic regulatory, T cell recruitment: Gut mucosal integrity breach and thymic T cells

    Zakariassen, Hannah Louise, Bendtsen, K. M., Tougaard, P. & Hansen, Axel Kornerup, 2019, In: European Journal of Inflammation. 17, p. 1-16

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Receptor Activator of Nuclear Factor kappa-B Ligand is Not Regulated During Chronic Osteomyelitis in Pigs

    Lüthje, F. L., Skovgaard, K., Jensen, Henrik Elvang, Blirup-Plum, Sophie Amalie, Henriksen, Nicole Lind, Aalbæk, Bent & Jensen, Louise Kruse, 2020, In: Journal of Comparative Pathology. 179, p. 7-24 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Rapid Postnatal Adaptation of Neurodevelopment in Pigs Born Late Preterm

    Nielsen, Charlotte Holme, Bladt Brandt, A., Thymann, Thomas, Obelitz-Ryom, K., Jiang, Pingping, Vanden Hole, C., van Ginneken, C., Pankratova, Stanislava & Sangild, Per Torp, 2019, In: Developmental Neuroscience. 40, 5-6, 15 p., 586–600.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Randall Selitto pressure algometry for assessment of bone-related pain in rats

    Falk, S., Ipsen, David Højland, Appel, C. K., Ugarak, A., Durup, D., Dickenson, A. H. & Heegaard, Anne-Marie, 2015, In: European Journal of Pain. 19, 3, p. 305-312 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    R-R interval variations influence the degree of mitral regurgitation in dogs with myxomatous mitral valve disease

    Reimann, Maria Josefine, Møller, J. E., Häggström, J., Markussen, Bo, Holen, A. E. W., Falk, B. T. & Olsen, Lisbeth Høier, 2013.

    Research output: Contribution to conference › Poster › Research

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