The Graduate Programme for In Vivo Pharmacology and Experimental Animals

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  1. 2019
  2. Published

    Anti-protozoal activity of extracts from chicory (Cichorium intybus) against Cryptosporidium parvum in cell culture

    Woolsey, I. D., Valente, Angela Hørdum, Williams, Andrew Richard, Thamsborg, Stig Milan, Simonsen, H. T. & Enemark, H. L., 2019, In: Scientific Reports. 9, 1, 9 p., 20414.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Antibiotic Resistance of Lactobacillus spp. and Streptococcus thermophilus Isolated from Chinese Fermented Milk Products

    Li, Y., Li, L., Kromann, Sofie, Chen, M., Shi, L. & Meng, H., 2019, In: Foodborne pathogens and disease. 16, 3, p. 221-228

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Atorvastatin and vitamin e accelerates NASH resolution by dietary intervention in a preclinical guinea pig model

    Klaebel, J. H., Skjødt, M., Skat-Rørdam, Josephine, Rakipovski, G., Ipsen, David Højland, Schou-Pedersen, A. M. V., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2019, In: Nutrients. 11, 11, 20 p., 2834.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Delayed insulin absorption correlates with alterations in subcutaneous depot kinetics in rats with diet‐induced obesity

    Gradel, Anna Katrina Jógvansdóttir, Porsgaard, T., Brockhoff, P. M. B., Seested, T., Lykkesfeldt, Jens & Refsgaard, H. H. F., 2019, In: Obesity Science & Practice. 5, 3, p. 281-288

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Effects of exercise and dietary protein sources on adiposity and insulin sensitivity in obese mice

    Fjære, E., Myrmel, L. S., Lützhøft, Ditte Olsen, Andersen, H., Holm, J. B., Kiilerich, P., Hannisdal, R., Liaset, B., Kristiansen, Karsten & Madsen, L., 2019, In: Journal of Nutritional Biochemistry. 66, p. 98-109

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    FortiColos - A multicentre study using bovine colostrum as a fortifier to human milk in very preterm infants: Study protocol for a randomised controlled pilot trial

    Ahnfeldt, Agnethe May, Hyldig, N., Li, Y., Kappel, S. S., Aunsholdt, L., Sangild, Per Torp & Zachariassen, G., 2019, In: Trials. 20, 9 p., 279.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Growth Restriction and Systemic Immune Development in Preterm Piglets

    Bæk, Ole, Sangild, Per Torp, Thymann, Thomas & Nguyen, Duc Ninh, 2019, In: Frontiers in Immunology. 10, 2402.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Guideline for Preclinical Studies of Bone Infections in Large Animals Based on a Systematic Review of 316 Non-Rodent Models

    Jensen, Louise Kruse, Henriksen, Nicole Lind, Blirup-Plum, Sophie Amalie & Jensen, Henrik Elvang, 2019, In: The Journal of bone and joint surgery. American volume. 101, 21, p. 1894-1903 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Guidelines for porcine models of human bacterial infections

    Jensen, Louise Kruse, Henriksen, Nicole Lind & Jensen, Henrik Elvang, 2019, In: Laboratory Animals. 53, 2, p. 125-136

    Research output: Contribution to journal › Review › Research › peer-review

  11. Published

    Health effects of exposure to diesel exhaust in diesel-powered trains

    Andersen, M. H. G., Frederiksen, M., Saber, A. T., Wils, Regitze Sølling, Fonseca, A. S., Koponen, I. K., Johannesson, S., Roursgaard, Martin, Loft, Steffen, Møller, Peter & Vogel, U., 2019, In: Particle and Fibre Toxicology. 16, 14 p., 21.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Human Milk Fortification with Bovine Colostrum Is Superior to Formula-Based Fortifiers to Prevent Gut Dysfunction, Necrotizing Enterocolitis, and Systemic Infection in Preterm Pigs

    Sun, Jing, Li, Y., Pan, X., Nguyen, Duc Ninh, Brunse, Anders, Bojesen, Anders Miki, Rudloff, S., Mortensen, M. S., Burrin, D. G. & Sangild, Per Torp, 2019, In: Journal of Parenteral and Enteral Nutrition. 43, 2, p. 252-262

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    In vitro synergy of sertraline and tetracycline cannot be reproduced in pigs orally challenged with a tetracycline resistant Escherichia coli

    Kromann, Sofie, Hvidtfeldt, A., Boye, M., Sørensen, Dorte Bratbo, Jørgensen, S., Nielsen, Jens Peter & Olsen, Rikke Heidemann, 2019, In: BMC Microbiology. 19, 1, 12 p., 12.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    In vivo gentamicin susceptibility test for prevention of bacterial biofilms in bone tissue and on implants

    Jensen, Louise Kruse, Bjarnsholt, Thomas, Kragh, K. N., Aalbæk, Bent, Henriksen, Nicole Lind, Blirup-Plum, Sophie Amalie, Pankoke, K., Petersen, A. & Jensen, Henrik Elvang, 2019, In: Antimicrobial Agents and Chemotherapy. 63, 2, 10 p., e01889-18.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Molecular drivers of non-alcoholic steatohepatitis are sustained in mild-to-late fibrosis progression in a guinea pig model

    Ipsen, David Højland, Skat-Rørdam, Josephine, Tsamouri, M. M., Latta, M., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2019, In: Molecular Genetics and Genomics. 294, 3, p. 649–661

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Myxømatøs mitralklapsygdom hos hund: Metoder til diagnostik af behandlingskrævende sygdomsstadier

    Reimann, Maria Josefine, Christiansen, L. B., Falk, T. & Olsen, Lisbeth Høier, 2019, In: Dansk Veterinaertidsskrift. 2019, 9, p. 28-32

    Research output: Contribution to journal › Review › Research › peer-review

  17. Published

    Parasites and plants - bioactive compounds with anti-parasitic effect from Cichorium intybus

    Valente, Angela Hørdum, de Roode, B. M., Williams, Andrew Richard, Simonsen, H. T. & Thamsborg, Stig Milan, 2019, In: Planta Medica. 85, 18, p. 1420-1420

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  18. Published

    Rapid Postnatal Adaptation of Neurodevelopment in Pigs Born Late Preterm

    Nielsen, Charlotte Holme, Bladt Brandt, A., Thymann, Thomas, Obelitz-Ryom, K., Jiang, Pingping, Vanden Hole, C., van Ginneken, C., Pankratova, Stanislava & Sangild, Per Torp, 2019, In: Developmental Neuroscience. 40, 5-6, 15 p., 586–600.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Reduced early life mucosal integrity decreases thymic cell counts and increases local, but not thymic regulatory, T cell recruitment: Gut mucosal integrity breach and thymic T cells

    Zakariassen, Hannah Louise, Bendtsen, K. M., Tougaard, P. & Hansen, Axel Kornerup, 2019, In: European Journal of Inflammation. 17, p. 1-16

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Short communication: Gut microbial colonization of the mouse colon using faecal transfer was equally effective when comparing rectal inoculation and oral inoculation based on 16S rRNA sequencing

    Lützhøft, Ditte Olsen, Sánchez-Alcoholado, L., Tougaard, P., Mentzel, Caroline M. Junker, Kot, Witold, Nielsen, Dennis Sandris & Hansen, Axel Kornerup, 2019, In: Research in Veterinary Science. 126, p. 227-232 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Telomere length and genotoxicity in the lung of rats following intragastric exposure to food-grade titanium dioxide and vegetable carbon particles

    Jensen, Ditte Marie, Løhr, M., Sheykhzade, Majid, Lykkesfeldt, Jens, Wils, Regitze Sølling, Loft, Steffen & Møller, Peter, 2019, In: Mutagenesis. 34, 2, p. 203-214 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. 2018
  23. Published

    Hemostatic parameters in preterm and full-term pigs of identical postnatal age

    Krogh, Anne Kirstine Havnsøe, Brunse, Anders, Thymann, Thomas, Bochsen, L. & Kristensen, Annemarie T., 20 Oct 2018.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  24. Published

    Brain Barrier Disruption and Region-Specific Neuronal Degeneration during Necrotizing Enterocolitis in Preterm Pigs

    Brunse, Anders, Abbaspour, A. & Sangild, Per Torp, 1 Oct 2018, In: Developmental Neuroscience. 40, 3, p. 198–208

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Antiparasitic activity of chicory (Cichorium intybus) and its natural bioactive compounds in livestock: a review

    Peña-Espinoza, M., Valente, Angela Hørdum, Thamsborg, Stig Milan, Simonsen, H. T., Boas, U., Enemark, H. L., López-Muñoz, R. & Williams, Andrew Richard, 22 Aug 2018, In: Parasites & Vectors. 11, 14 p., 475.

    Research output: Contribution to journal › Review › Research › peer-review

  26. Published

    Long-term diet-induced hypertension in rats is associated with reduced expression and function of small artery SKCa, IKCa, and Kir2.1 channels

    Gradel, Anna Katrina Jógvansdóttir, Salomonsson, M., Sorensen, Charlotte Mehlin, von Holstein-Rathlou, Niels-Henrik & Jensen, Lars Jørn, 28 Feb 2018, In: Clinical Science. 132, 4, p. 461–474 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Vasomotor function in rat arteries after ex vivo and intragastric exposure to food-grade titanium dioxide and vegetable carbon particles

    Jensen, Ditte Marie, Christophersen, D. V., Sheykhzade, Majid, Skovsted, Gry Freja, Lykkesfeldt, Jens, Münter, R., Roursgaard, Martin, Loft, Steffen & Møller, Peter, 26 Feb 2018, In: Particle and Fibre Toxicology. 15, p. 1-18 12.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Searching for assay controls for the Fpg- and hOGG1-modified comet assay

    Møller, Peter, Jantzen, K., Løhr, M., Andersen, M. H., Jensen, Ditte Marie, Roursgaard, Martin, Danielsen, P. H., Jensen, Annie & Loft, Steffen, 24 Feb 2018, In: Mutagenesis. 33, 1, p. 9-19 11 p.

    Research output: Contribution to journal › Review › Research › peer-review

  29. Published

    A comparison of various methods of blood sampling in mice and rats: Effects on animal welfare

    Sreelatha, Harikrishnan Vijayakumar, Hansen, Axel Kornerup, Abelson, Klas & Sørensen, Dorte Bratbo, 2018, In: Laboratory Animals. 52, 3, p. 253-264

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Angiotensin-converting enzyme activity in Cavalier King Charles Spaniels with an ACE gene polymorphism and myxomatous mitral valve disease

    Meurs, K. M., Olsen, Lisbeth Høier, Reimann, Maria Josefine, Keene, B. W., Atkins, C. E., Adin, D., Aona, B., Condit, J., Defrancesco, T., Reina-Doreste, Y., Stern, J. A., Tou, S., Ward, J. & Woodruff, K., 2018, In: Pharmacogenetics and Genomics. 28, 2, p. 37-40 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Dietary fat stimulates development of NAFLD more potently than dietary fructose in Sprague-Dawley rats

    Jensen, Victoria Svop, Hvid, H., Damgaard, J., Nygaard, H., Ingvorsen, C., Wulff, E. M., Lykkesfeldt, Jens & Fledelius, C., 2018, In: Diabetology and Metabolic Syndrome. 10, 13 p., 4.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Factors Affecting the Absorption of Subcutaneously Administered Insulin: Effect on Variability

    Gradel, Anna Katrina Jógvansdóttir, Porsgaard, T., Lykkesfeldt, Jens, Seested, T., Gram-Nielsen, S., Kristensen, N. R. & Refsgaard, H., 2018, In: Journal of Diabetes Research. 2018, 17 p., 1205121.

    Research output: Contribution to journal › Review › Research › peer-review

  33. Published

    Liraglutide Decreases Hepatic Inflammation and Injury in Advanced Lean Non-Alcoholic Steatohepatitis

    Ipsen, David Højland, Rolin, B., Rakipovski, G., Skovsted, Gry Freja, Madsen, A., Kolstrup, S., Schou-Pedersen, A. M., Skat-Rørdam, Josephine, Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2018, In: Basic & Clinical Pharmacology & Toxicology. 123, 3, p. 704-713

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Long term Westernized diet leads to region-specific changes in brain signaling mechanisms

    Hansen, S. N., Ipsen, David Højland, Schou-Pedersen, A. M., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2018, In: Neuroscience Letters. 676, p. 85-91 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease

    Ipsen, David Højland, Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2018, In: Cellular and Molecular Life Sciences. 75, 18, p. 3313-3327 15 p.

    Research output: Contribution to journal › Review › Research › peer-review

  36. Published

    Necrotizing enterocolitis is associated with acute brain responses in preterm pigs

    Sun, Jing, Pan, X., Christiansen, Line Iadsatian, Yuan, X., Skovgaard, K., Chatterton, Dereck Edward Winston, Kaalund, S. S., Gao, Fei, Sangild, Per Torp & Pankratova, Stanislava, 2018, In: Journal of Neuroinflammation. 15, 13 p., 180.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Nutrient Fortification of Human Donor Milk Affects Intestinal Function and Protein Metabolism in Preterm Pigs

    Sun, Jing, Li, Y., Nguyen, Duc Ninh, Mortensen, M. S., van den Akker, C. H. P., Skeath, T., Pors, S. E., Pankratova, Stanislava, Rudloff, S., Sørensen, Søren Johannes, Burrin, D. G., Thymann, Thomas & Sangild, Per Torp, 2018, In: Journal of Nutrition. 148, 3, p. 336-347 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Prenatal Intra-Amniotic Endotoxin Induces Fetal Gut and Lung Immune Responses and Postnatal Systemic Inflammation in Preterm Pigs

    Nguyen, Duc Ninh, Thymann, Thomas, Goericke-Pesch, S. K., Ren, S., Wei, W., Skovgaard, K., Damborg, Peter Panduro, Brunse, Anders, van Gorp, C., Kramer, B. W., Wolfs, T. G. & Sangild, Per Torp, 2018, In: American Journal of Pathology. 188, 11, p. 2629-2643 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Telomere dynamics and cellular senescence: an emerging field in environmental and occupational toxicology

    Møller, Peter, Wils, Regitze Sølling, Jensen, Ditte Marie, Andersen, M. H. G. & Roursgaard, Martin, 2018, In: Critical Reviews in Toxicology. 48, 9, p. 761-788 28 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    The impact of exercise training and resveratrol supplementation on gut microbiota composition in high-fat diet fed mice

    Brandt, N., Kotowska, D., Kristensen, C. M., Olesen, J., Lützhøft, Ditte Olsen, Halling, Jens Frey, Hansen, M., Al-Soud, W. A., Hansen, Lars Hestbjerg, Kiilerich, P. & Pilegaard, Henriette, 2018, In: Physiological Reports. 6, 20, p. 1-11 e13881.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Vasomotor dysfunction in human subcutaneous arteries exposed ex vivo to food-grade titanium dioxide

    Jensen, Ditte Marie, Skovsted, Gry Freja, Lykkesfeldt, Jens, Dreier, R., Berg, J. O., Jeppesen, J. L., Sheykhzade, Majid, Loft, Steffen & Møller, Peter, 2018, In: Food and Chemical Toxicology. 120, p. 321-327 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. 2017
  43. Published

    Stability and development of psychotic symptoms and the use of antipsychotic medication - long-term follow-up

    Gotfredsen, D. R., Wils, Regitze Sølling, Hjorthøj, C., Austin, Stephen Fitzgerald, Albert, N., Secher, R. G., Thorup, Anne, Mors, O. & Nordentoft, Merete, Sep 2017, In: Psychological Medicine. 47, 12, p. 2118-2129 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Pasteurization Procedures for Donor Human Milk Affect Body Growth, Intestinal Structure, and Resistance against Bacterial Infections in Preterm Pigs

    Li, Y., Nguyen, Duc Ninh, de Waard, M., Christensen, Lars, Zhou, P., Jiang, Pingping, Sun, Jing, Bojesen, Anders Miki, Lauridsen, C., Lykkesfeldt, Jens, Dalsgaard, T. K., Bering, S. B. & Sangild, Per Torp, Jun 2017, In: Journal of Nutrition. 147, 6, p. 1121-1130

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Antipsychotic medication and remission of psychotic symptoms 10 years after a first-episode psychosis

    Wils, Regitze Sølling, Gotfredsen, D. R., Hjorthøj, C., Austin, Stephen Fitzgerald, Albert, N., Secher, R. G., Thorup, Anne, Mors, O. & Nordentoft, Merete, 2017, In: Schizophrenia Research. 182, p. 42-48

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Assessment of evidence for nanosized titanium dioxide-generated DNA strand breaks and oxidatively damaged DNA in cells and animal models

    Møller, Peter, Jensen, Ditte Marie, Wils, Regitze Sølling, Guerra Andersen, M. H., Danielsen, P. H. & Roursgaard, Martin, 2017, In: Nanotoxicology. 11, 9-10, p. 1237-1256 20 p.

    Research output: Contribution to journal › Review › Research › peer-review

  47. Published

    Buprenorphine alleviation of pain does not compromise the rat monoarthritic pain model

    Berke, M. S. & Abelson, Klas, 2017, In: Scandinavian Journal of Pain. 16, p. 167-167 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  48. Published

    Elevated levels of circulating cell-free DNA and neutrophil proteins are associated with neonatal sepsis and necrotizing enterocolitis in immature mice, pigs and infants

    Nguyen, Duc Ninh, Stensballe, A., Lai, J. C. Y., Jiang, Pingping, Brunse, Anders, Li, Y., Sun, Jing, Mallard, C., Skeath, T., Embleton, N. D., Berrington, J. E. & Sangild, Per Torp, 2017, In: Innate Immunity. 23, 6, p. 524-536 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Markers of Oxidative Stress in Dogs with Myxomatous Mitral Valve Disease are Influenced by Sex, Neuter Status, and Serum Cholesterol Concentration

    Reimann, Maria Josefine, Haggstrom, J., Moller, J. E., Lykkesfeldt, Jens, Falk, T. & Olsen, Lisbeth Høier, 2017, In: Journal of Veterinary Internal Medicine. 31, 2, p. 295-302 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Mitral Regurgitation Severity and Left Ventricular Systolic Dimension Predict Survival in Young Cavalier King Charles Spaniels

    Reimann, Maria Josefine, Moller, J. E., Haggstrom, J., Martinussen, Torben, Zatrazemi, S. S. C., Svanholm, L., Nielsen, L. B. M., Pedersen, H. D. & Olsen, Lisbeth Høier, 2017, In: Journal of Veterinary Internal Medicine. 31, 4, p. 1008-1016 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. 2016
  52. Published

    Dyslipidemia: Obese or Not Obese-That Is Not the Question

    Ipsen, David Højland, Tveden-Nyborg, Pernille & Lykkesfeldt, Jens, Dec 2016, In: Current Obesity Reports. 5, 4, p. 405-412

    Research output: Contribution to journal › Review › Research › peer-review

  53. Published

    CEREBROSPINAL FLUID FROM PRETERM PIGS WITH NECROTIZING ENTEROCOLITIS HAS ALTERED CYTOKINE PROFILE AND PROMOTES HIPPOCAMPAL NEURITOGENESIS

    Pankratova, Stanislava, Sun, Jing, Li, Y. & Sangild, Per Torp, Nov 2016, In: European Journal of Pediatrics. 175, 11, p. 1688-1688 1 p., EAPS-0806.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  54. Published

    EARLY ENTERAL FEEDING REDUCES SEPSIS RESPONSE AND NEUROINFLAMMATION IN A PIG MODEL OF NEONATAL BLOODSTREAM INFECTION

    Brunse, Anders, Worsøe, P. S., Pors, S. E., Skovgaard, K. & Sangild, Per Torp, Nov 2016, In: European Journal of Pediatrics. 175, 11, p. 1497-1497 1 p., 307, EAPS-0930.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

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