Dyslipidemia: Obese or Not Obese-That Is Not the Question
Research output: Contribution to journal › Review › Research › peer-review
Purpose of Review
Purpose of review: It is becoming increasingly clear that some obese individuals do not develop dyslipidemia and instead remain healthy, while some normal weight individuals become dyslipidemic and unhealthy.
Recent Findings
The present review examines the similarities and differences between healthy and unhealthy individuals with and without obesity and discusses putative underlying mechanisms of dyslipidemia.
Summary
The presence of dyslipidemia and compromised metabolic health in both lean and obese individuals suggests that the obese phenotype per se does not represent a main independent risk factor for the development of dyslipidemia and that dyslipidemia, rather than obesity, may be the driver of metabolic diseases. Notably, adipose tissue dysfunction and ectopic lipid deposition, in particular in the liver, seems a common trait of unhealthy individuals.
Purpose of review: It is becoming increasingly clear that some obese individuals do not develop dyslipidemia and instead remain healthy, while some normal weight individuals become dyslipidemic and unhealthy.
Recent Findings
The present review examines the similarities and differences between healthy and unhealthy individuals with and without obesity and discusses putative underlying mechanisms of dyslipidemia.
Summary
The presence of dyslipidemia and compromised metabolic health in both lean and obese individuals suggests that the obese phenotype per se does not represent a main independent risk factor for the development of dyslipidemia and that dyslipidemia, rather than obesity, may be the driver of metabolic diseases. Notably, adipose tissue dysfunction and ectopic lipid deposition, in particular in the liver, seems a common trait of unhealthy individuals.
Original language | English |
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Journal | Current Obesity Reports |
Volume | 5 |
Issue number | 4 |
Pages (from-to) | 405-412 |
ISSN | 2162-4968 |
DOIs | |
Publication status | Published - Dec 2016 |
- Dyslipidemia, Obesity, Metabolically healthy obese, Metabolically unhealthy obese, Metabolically unhealthy normal weight
Research areas
ID: 169284477