Antipsychotic medication and remission of psychotic symptoms 10 years after a first-episode psychosis
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Antipsychotic medication and remission of psychotic symptoms 10 years after a first-episode psychosis. / Wils, Regitze Sølling; Gotfredsen, Ditte Resendal; Hjorthøj, Carsten; Austin, Stephen F; Albert, Nikolai; Secher, Rikke Gry; Thorup, Anne Amalie Elgaard; Mors, Ole; Nordentoft, Merete.
In: Schizophrenia Research, Vol. 182, 2017, p. 42-48.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Antipsychotic medication and remission of psychotic symptoms 10 years after a first-episode psychosis
AU - Wils, Regitze Sølling
AU - Gotfredsen, Ditte Resendal
AU - Hjorthøj, Carsten
AU - Austin, Stephen F
AU - Albert, Nikolai
AU - Secher, Rikke Gry
AU - Thorup, Anne Amalie Elgaard
AU - Mors, Ole
AU - Nordentoft, Merete
N1 - Copyright © 2016 Elsevier B.V. All rights reserved.
PY - 2017
Y1 - 2017
N2 - BACKGROUND: Several national guidelines recommend continuous use of antipsychotic medication after a psychotic episode in order to minimize the risk of relapse. However some studies have identified a subgroup of patients who obtain remission of psychotic symptoms while not being on antipsychotic medication for a period of time. This study investigated the long-term outcome and characteristics of patients in remission of psychotic symptoms with no use of antipsychotic medication at the 10-year follow-up.METHODS: The study was a cohort study including 496 patients diagnosed with schizophrenia spectrum disorders (ICD 10: F20 and F22-29). Patients were included in the Danish OPUS Trial and followed up 10years after inclusion, where patient data was collected on socio-demographic factors, psychopathology, level of functioning and medication.FINDINGS: 61% of the patients from the original cohort attended the 10-year follow up and 30% of these had remission of psychotic symptoms at the time of the 10-year follow up with no current use of antipsychotic medication. This outcome was associated with female gender, high GAF-F score, participation in the labour market and absence of substance abuse.CONCLUSION: Our results describe a subgroup of patients who obtained remission while not being on antipsychotic medication at the 10-year follow-up. The finding calls for further investigation on a more individualized approach to long-term treatment with antipsychotic medication.
AB - BACKGROUND: Several national guidelines recommend continuous use of antipsychotic medication after a psychotic episode in order to minimize the risk of relapse. However some studies have identified a subgroup of patients who obtain remission of psychotic symptoms while not being on antipsychotic medication for a period of time. This study investigated the long-term outcome and characteristics of patients in remission of psychotic symptoms with no use of antipsychotic medication at the 10-year follow-up.METHODS: The study was a cohort study including 496 patients diagnosed with schizophrenia spectrum disorders (ICD 10: F20 and F22-29). Patients were included in the Danish OPUS Trial and followed up 10years after inclusion, where patient data was collected on socio-demographic factors, psychopathology, level of functioning and medication.FINDINGS: 61% of the patients from the original cohort attended the 10-year follow up and 30% of these had remission of psychotic symptoms at the time of the 10-year follow up with no current use of antipsychotic medication. This outcome was associated with female gender, high GAF-F score, participation in the labour market and absence of substance abuse.CONCLUSION: Our results describe a subgroup of patients who obtained remission while not being on antipsychotic medication at the 10-year follow-up. The finding calls for further investigation on a more individualized approach to long-term treatment with antipsychotic medication.
KW - Adolescent
KW - Adult
KW - Antipsychotic Agents
KW - Female
KW - Humans
KW - Longitudinal Studies
KW - Male
KW - Middle Aged
KW - Psychiatric Status Rating Scales
KW - Psychotic Disorders
KW - Recurrence
KW - Treatment Outcome
KW - Young Adult
KW - Journal Article
U2 - 10.1016/j.schres.2016.10.030
DO - 10.1016/j.schres.2016.10.030
M3 - Journal article
C2 - 28277310
VL - 182
SP - 42
EP - 48
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
ER -
ID: 188192314