Increased serum C-reactive protein concentrations in dogs with congestive heart failure due to myxomatous mitral valve disease

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Increased serum C-reactive protein concentrations in dogs with congestive heart failure due to myxomatous mitral valve disease. / Reimann, M. J.; Ljungvall, I.; Hillstrom, A.; Møller, J. E.; Hagman, R.; Falk, T.; Hoglund, K.; Haggstrom, J.; Olsen, Lisbeth Høier.

In: Veterinary Journal, Vol. 209, 03.2016, p. 113-118.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Reimann, MJ, Ljungvall, I, Hillstrom, A, Møller, JE, Hagman, R, Falk, T, Hoglund, K, Haggstrom, J & Olsen, LH 2016, 'Increased serum C-reactive protein concentrations in dogs with congestive heart failure due to myxomatous mitral valve disease', Veterinary Journal, vol. 209, pp. 113-118. https://doi.org/10.1016/j.tvjl.2015.12.006

APA

Reimann, M. J., Ljungvall, I., Hillstrom, A., Møller, J. E., Hagman, R., Falk, T., Hoglund, K., Haggstrom, J., & Olsen, L. H. (2016). Increased serum C-reactive protein concentrations in dogs with congestive heart failure due to myxomatous mitral valve disease. Veterinary Journal, 209, 113-118. https://doi.org/10.1016/j.tvjl.2015.12.006

Vancouver

Reimann MJ, Ljungvall I, Hillstrom A, Møller JE, Hagman R, Falk T et al. Increased serum C-reactive protein concentrations in dogs with congestive heart failure due to myxomatous mitral valve disease. Veterinary Journal. 2016 Mar;209:113-118. https://doi.org/10.1016/j.tvjl.2015.12.006

Author

Reimann, M. J. ; Ljungvall, I. ; Hillstrom, A. ; Møller, J. E. ; Hagman, R. ; Falk, T. ; Hoglund, K. ; Haggstrom, J. ; Olsen, Lisbeth Høier. / Increased serum C-reactive protein concentrations in dogs with congestive heart failure due to myxomatous mitral valve disease. In: Veterinary Journal. 2016 ; Vol. 209. pp. 113-118.

Bibtex

@article{bf674eb602894881b670fe48cc218d82,
title = "Increased serum C-reactive protein concentrations in dogs with congestive heart failure due to myxomatous mitral valve disease",
abstract = "Cardiovascular disease in humans and dogs is associated with mildly increased circulating concentrations of C-reactive protein (CRP). Few studies have evaluated associations between circulating CRP and canine myxomatous mitral valve disease (MMVD) and the results reported have been divergent. The aim of this study was to investigate whether serum concentrations of CRP, determined using a novel automated canine-specific high -sensitivity CRP assay (Gentian hsCRP), were associated with severity of MMVD and selected clinical variables in dogs. The study included 188 client-owned dogs with different severities of MMVD. Dogs were classified based on ACVIM consensus statement guidelines (group A, n = 58; group BI, n = 56; group B2, n = 38; group C, n = 36). Data were analysed using descriptive statistics and multiple regression analysis. Dogs with congestive heart failure (CHF; group C) had significantly higher CRP concentrations (median, 2.65 mg/L; quartile 1 -quartile 3, 1.09-5.09) compared to dogs in groups A (median, 0.97 mg/L; quartile 1-quartile 3, <0.50-1.97; P = 0.001), B1 (median, 0.78 mg/L; quartile 1 -quartile 3, <0.50-1.73, P < 0.0001) and B2 (median, 0.60 mg/L; quartile 1-quartile 3, <0.50-1.23; P <0.0001). Other variables reflecting disease severity, including left atrial to aortic root ratio (P= 0.0002, adjusted r(2) = 0.07) and left ventricular end diastolic diameter normalised for bodyweight (P = 0.0005, adjusted r(2) = 0.06), were positively associated with CRP concentration, but the association disappeared if dogs with CHF were excluded from analysis. In conclusion, slightly higher CRP concentrations were found in dogs with CHF whereas severity of asymptomatic MMVD showed no association with CRP concentrations",
keywords = "CRP, Mitral regurgitation, Dog, Inflammation, Valvular disease",
author = "Reimann, {M. J.} and I. Ljungvall and A. Hillstrom and M{\o}ller, {J. E.} and R. Hagman and T. Falk and K. Hoglund and J. Haggstrom and Olsen, {Lisbeth H{\o}ier}",
year = "2016",
month = mar,
doi = "10.1016/j.tvjl.2015.12.006",
language = "English",
volume = "209",
pages = "113--118",
journal = "The Veterinary Journal",
issn = "1090-0233",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Increased serum C-reactive protein concentrations in dogs with congestive heart failure due to myxomatous mitral valve disease

AU - Reimann, M. J.

AU - Ljungvall, I.

AU - Hillstrom, A.

AU - Møller, J. E.

AU - Hagman, R.

AU - Falk, T.

AU - Hoglund, K.

AU - Haggstrom, J.

AU - Olsen, Lisbeth Høier

PY - 2016/3

Y1 - 2016/3

N2 - Cardiovascular disease in humans and dogs is associated with mildly increased circulating concentrations of C-reactive protein (CRP). Few studies have evaluated associations between circulating CRP and canine myxomatous mitral valve disease (MMVD) and the results reported have been divergent. The aim of this study was to investigate whether serum concentrations of CRP, determined using a novel automated canine-specific high -sensitivity CRP assay (Gentian hsCRP), were associated with severity of MMVD and selected clinical variables in dogs. The study included 188 client-owned dogs with different severities of MMVD. Dogs were classified based on ACVIM consensus statement guidelines (group A, n = 58; group BI, n = 56; group B2, n = 38; group C, n = 36). Data were analysed using descriptive statistics and multiple regression analysis. Dogs with congestive heart failure (CHF; group C) had significantly higher CRP concentrations (median, 2.65 mg/L; quartile 1 -quartile 3, 1.09-5.09) compared to dogs in groups A (median, 0.97 mg/L; quartile 1-quartile 3, <0.50-1.97; P = 0.001), B1 (median, 0.78 mg/L; quartile 1 -quartile 3, <0.50-1.73, P < 0.0001) and B2 (median, 0.60 mg/L; quartile 1-quartile 3, <0.50-1.23; P <0.0001). Other variables reflecting disease severity, including left atrial to aortic root ratio (P= 0.0002, adjusted r(2) = 0.07) and left ventricular end diastolic diameter normalised for bodyweight (P = 0.0005, adjusted r(2) = 0.06), were positively associated with CRP concentration, but the association disappeared if dogs with CHF were excluded from analysis. In conclusion, slightly higher CRP concentrations were found in dogs with CHF whereas severity of asymptomatic MMVD showed no association with CRP concentrations

AB - Cardiovascular disease in humans and dogs is associated with mildly increased circulating concentrations of C-reactive protein (CRP). Few studies have evaluated associations between circulating CRP and canine myxomatous mitral valve disease (MMVD) and the results reported have been divergent. The aim of this study was to investigate whether serum concentrations of CRP, determined using a novel automated canine-specific high -sensitivity CRP assay (Gentian hsCRP), were associated with severity of MMVD and selected clinical variables in dogs. The study included 188 client-owned dogs with different severities of MMVD. Dogs were classified based on ACVIM consensus statement guidelines (group A, n = 58; group BI, n = 56; group B2, n = 38; group C, n = 36). Data were analysed using descriptive statistics and multiple regression analysis. Dogs with congestive heart failure (CHF; group C) had significantly higher CRP concentrations (median, 2.65 mg/L; quartile 1 -quartile 3, 1.09-5.09) compared to dogs in groups A (median, 0.97 mg/L; quartile 1-quartile 3, <0.50-1.97; P = 0.001), B1 (median, 0.78 mg/L; quartile 1 -quartile 3, <0.50-1.73, P < 0.0001) and B2 (median, 0.60 mg/L; quartile 1-quartile 3, <0.50-1.23; P <0.0001). Other variables reflecting disease severity, including left atrial to aortic root ratio (P= 0.0002, adjusted r(2) = 0.07) and left ventricular end diastolic diameter normalised for bodyweight (P = 0.0005, adjusted r(2) = 0.06), were positively associated with CRP concentration, but the association disappeared if dogs with CHF were excluded from analysis. In conclusion, slightly higher CRP concentrations were found in dogs with CHF whereas severity of asymptomatic MMVD showed no association with CRP concentrations

KW - CRP

KW - Mitral regurgitation

KW - Dog

KW - Inflammation

KW - Valvular disease

U2 - 10.1016/j.tvjl.2015.12.006

DO - 10.1016/j.tvjl.2015.12.006

M3 - Journal article

C2 - 26831162

VL - 209

SP - 113

EP - 118

JO - The Veterinary Journal

JF - The Veterinary Journal

SN - 1090-0233

ER -

ID: 165609463