Activation of the renal GLP-1R leads to expression of Ren1 in the renal vascular tree

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Activation of the renal GLP-1R leads to expression of Ren1 in the renal vascular tree. / Bjørnholm, Katrine Dahl; Ougaard, Maria Elm; Skovsted, Gry Freja; Knudsen, Lotte Bjerre; Pyke, Charles.

In: Endocrinology, Diabetes and Metabolism, Vol. 4, No. 3, e00234, 2021.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bjørnholm, KD, Ougaard, ME, Skovsted, GF, Knudsen, LB & Pyke, C 2021, 'Activation of the renal GLP-1R leads to expression of Ren1 in the renal vascular tree', Endocrinology, Diabetes and Metabolism, vol. 4, no. 3, e00234. https://doi.org/10.1002/edm2.234

APA

Bjørnholm, K. D., Ougaard, M. E., Skovsted, G. F., Knudsen, L. B., & Pyke, C. (2021). Activation of the renal GLP-1R leads to expression of Ren1 in the renal vascular tree. Endocrinology, Diabetes and Metabolism, 4(3), [e00234]. https://doi.org/10.1002/edm2.234

Vancouver

Bjørnholm KD, Ougaard ME, Skovsted GF, Knudsen LB, Pyke C. Activation of the renal GLP-1R leads to expression of Ren1 in the renal vascular tree. Endocrinology, Diabetes and Metabolism. 2021;4(3). e00234. https://doi.org/10.1002/edm2.234

Author

Bjørnholm, Katrine Dahl ; Ougaard, Maria Elm ; Skovsted, Gry Freja ; Knudsen, Lotte Bjerre ; Pyke, Charles. / Activation of the renal GLP-1R leads to expression of Ren1 in the renal vascular tree. In: Endocrinology, Diabetes and Metabolism. 2021 ; Vol. 4, No. 3.

Bibtex

@article{def8e796a4a84170b721a48aa60b12be,
title = "Activation of the renal GLP-1R leads to expression of Ren1 in the renal vascular tree",
abstract = "The GLP-1 receptor (GLP-1R) in the kidney is expressed exclusively in vascular smooth muscle cells in arteries and arterioles. Downstream effects of the activation of the renal vascular GLP-1R are elusive but may involve regulation of the renin-angiotensin-aldosterone system (RAAS). The expression of Ren1 in the mouse renal vasculature was investigated by in situ hybridization after a single subcutaneous dose of liraglutide, semaglutide and after repeated injections of liraglutide. Single and repeated exposure to GLP-1R agonists induced expression of Ren1 in the renal vascular smooth muscle cell compartment compared with vehicle injected controls (p <.0001) for both semaglutide and liraglutide. The present data show a robust induction of Ren1 expression in the vascular smooth muscle cells of the kidney after single and repeated GLP-1R activation and this renin recruitment may be involved in the effects of GLP-1R agonist treatment on kidney disease.",
keywords = "GLP-1, GLP-1 receptor, GLP-1R agonists, in situ hybridization, renal vasculature, renin recruitment",
author = "Bj{\o}rnholm, {Katrine Dahl} and Ougaard, {Maria Elm} and Skovsted, {Gry Freja} and Knudsen, {Lotte Bjerre} and Charles Pyke",
year = "2021",
doi = "10.1002/edm2.234",
language = "English",
volume = "4",
journal = "Endocrinology, Diabetes and Metabolism",
issn = "2398-9238",
publisher = "Wiley",
number = "3",

}

RIS

TY - JOUR

T1 - Activation of the renal GLP-1R leads to expression of Ren1 in the renal vascular tree

AU - Bjørnholm, Katrine Dahl

AU - Ougaard, Maria Elm

AU - Skovsted, Gry Freja

AU - Knudsen, Lotte Bjerre

AU - Pyke, Charles

PY - 2021

Y1 - 2021

N2 - The GLP-1 receptor (GLP-1R) in the kidney is expressed exclusively in vascular smooth muscle cells in arteries and arterioles. Downstream effects of the activation of the renal vascular GLP-1R are elusive but may involve regulation of the renin-angiotensin-aldosterone system (RAAS). The expression of Ren1 in the mouse renal vasculature was investigated by in situ hybridization after a single subcutaneous dose of liraglutide, semaglutide and after repeated injections of liraglutide. Single and repeated exposure to GLP-1R agonists induced expression of Ren1 in the renal vascular smooth muscle cell compartment compared with vehicle injected controls (p <.0001) for both semaglutide and liraglutide. The present data show a robust induction of Ren1 expression in the vascular smooth muscle cells of the kidney after single and repeated GLP-1R activation and this renin recruitment may be involved in the effects of GLP-1R agonist treatment on kidney disease.

AB - The GLP-1 receptor (GLP-1R) in the kidney is expressed exclusively in vascular smooth muscle cells in arteries and arterioles. Downstream effects of the activation of the renal vascular GLP-1R are elusive but may involve regulation of the renin-angiotensin-aldosterone system (RAAS). The expression of Ren1 in the mouse renal vasculature was investigated by in situ hybridization after a single subcutaneous dose of liraglutide, semaglutide and after repeated injections of liraglutide. Single and repeated exposure to GLP-1R agonists induced expression of Ren1 in the renal vascular smooth muscle cell compartment compared with vehicle injected controls (p <.0001) for both semaglutide and liraglutide. The present data show a robust induction of Ren1 expression in the vascular smooth muscle cells of the kidney after single and repeated GLP-1R activation and this renin recruitment may be involved in the effects of GLP-1R agonist treatment on kidney disease.

KW - GLP-1

KW - GLP-1 receptor

KW - GLP-1R agonists

KW - in situ hybridization

KW - renal vasculature

KW - renin recruitment

U2 - 10.1002/edm2.234

DO - 10.1002/edm2.234

M3 - Journal article

C2 - 34277961

AN - SCOPUS:85102654727

VL - 4

JO - Endocrinology, Diabetes and Metabolism

JF - Endocrinology, Diabetes and Metabolism

SN - 2398-9238

IS - 3

M1 - e00234

ER -

ID: 259101357