Dyslipidemia: Obese or Not Obese-That Is Not the Question
Research output: Contribution to journal › Review › Research › peer-review
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Dyslipidemia : Obese or Not Obese-That Is Not the Question. / Ipsen, David H.; Tveden-Nyborg, Pernille; Lykkesfeldt, Jens.
In: Current Obesity Reports, Vol. 5, No. 4, 12.2016, p. 405-412.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Dyslipidemia
T2 - Obese or Not Obese-That Is Not the Question
AU - Ipsen, David H.
AU - Tveden-Nyborg, Pernille
AU - Lykkesfeldt, Jens
PY - 2016/12
Y1 - 2016/12
N2 - Purpose of ReviewPurpose of review: It is becoming increasingly clear that some obese individuals do not develop dyslipidemia and instead remain healthy, while some normal weight individuals become dyslipidemic and unhealthy.Recent FindingsThe present review examines the similarities and differences between healthy and unhealthy individuals with and without obesity and discusses putative underlying mechanisms of dyslipidemia.SummaryThe presence of dyslipidemia and compromised metabolic health in both lean and obese individuals suggests that the obese phenotype per se does not represent a main independent risk factor for the development of dyslipidemia and that dyslipidemia, rather than obesity, may be the driver of metabolic diseases. Notably, adipose tissue dysfunction and ectopic lipid deposition, in particular in the liver, seems a common trait of unhealthy individuals.
AB - Purpose of ReviewPurpose of review: It is becoming increasingly clear that some obese individuals do not develop dyslipidemia and instead remain healthy, while some normal weight individuals become dyslipidemic and unhealthy.Recent FindingsThe present review examines the similarities and differences between healthy and unhealthy individuals with and without obesity and discusses putative underlying mechanisms of dyslipidemia.SummaryThe presence of dyslipidemia and compromised metabolic health in both lean and obese individuals suggests that the obese phenotype per se does not represent a main independent risk factor for the development of dyslipidemia and that dyslipidemia, rather than obesity, may be the driver of metabolic diseases. Notably, adipose tissue dysfunction and ectopic lipid deposition, in particular in the liver, seems a common trait of unhealthy individuals.
KW - Dyslipidemia
KW - Obesity
KW - Metabolically healthy obese
KW - Metabolically unhealthy obese
KW - Metabolically unhealthy normal weight
U2 - 10.1007/s13679-016-0232-9
DO - 10.1007/s13679-016-0232-9
M3 - Review
C2 - 27687811
VL - 5
SP - 405
EP - 412
JO - Current Obesity Reports
JF - Current Obesity Reports
SN - 2162-4968
IS - 4
ER -
ID: 169284477